Monday, November 2, 2020

Heart Care & COVID-19 Immune System

 CARDIAC CARE

With each passing year, the risks posed by cardiovascular diseases (CVD) seem to grow in magnitude. On World Heart Day (29th September), researchers need to gain more knowledge by attending several webinar series to throw light on different topics pertaining to the heart and related ailments. The prediction and prevention of CVD is a must, since a lot of people suffering more when compared to the last 5 or 10 years.

Many countries were not ready with the requisite health infrastructure when Covid suddenly hit them. Similarly, the sheer number of people who are likely to end up with heart diseases is disquieting. But the good news is that 70 percent of CVDs can be tackled through lifestyle choice; almost 28 percent of risk can be reduced by simply not smoking and around 17 percent with exercises.


Many patients who come with CVD are as young as 26. They have just finished college and are in the early years of their career. The most common factors leading them to CVD are stress, smoking, and many other lifestyle factors. Among non-communicable diseases, CVD is the leading cause of death. It is important to take care of what you eat. Avoid eating too many carbs, exercise for 20-30 minutes five days a week, and get good sleep. For detecting erratic heart rhythms, the concept of electrophysiology is used. It is a widely known fact that genetically, Indians are prone to heart ailments. Some other factors need to be changed in our day-to-day life, such as calorie intake. We love excess oil, salt, and sugar but these are very detrimental for our heart. The idea is not how long you live but how well you live. Sit down and eat. Do not use gadgets and television while eating and watch your portion size. Diabetics do not often experience symptoms pointing to hypertension or heart ailments and for that, we need to go for regular check-ups.

Today AI can predict heart ailments and monitor the risk factors. When people come with symptoms of giddiness and palpitations, a small patch is stuck to their body and they are sent home. They go about their routine activities even as the machine continuously records their heart rhythm.

In the current scenario on daily life in this pandemic time, we now know that if you people wear a mask, you may not get infected. Similarly, you should not neglect symptoms. Heart diseases have seemingly reduced during Covid. It could be because of ample rest, proper eating, and exercise.

Healthcare has seen sweeping changes over the past decade thanks to the innovation and research happening in that space. In the next three years, telemonitoring is going to create an explosive revolution.

Robotics and minimally invasive technologies have changed the way surgeries are conducted today. We have got into the big league with robotics. The advantages have magnified by 10 times and the system is foolproof. Everyone in the operating room can see what is happening and there is hardly any blood loss or pain. Trauma is thus avoided. Splitting the chest open was always a concern and there are patients who will still need open-heart surgeries. But with these advancements, we have been able to reduce the hospital stay after the surgery for the elderly and for younger patients who have to get back to work.

COVID-19 IMMUNE SYSTEM

Immunity against COVID-19 may persist for at least five months after being infected with the SARS-CoV-2 virus, according to a study led by an Indian-origin researcher in the US.

The researchers from the University of Arizona studied the production of antibodies from a sample of nearly 6,000 people infected with the novel coronavirus.

"We clearly see high-quality antibodies still being produced five to seven months after SARS-CoV-2 infection," said Deepta Bhattacharya, associate professor at the University of Arizona.

"Many concerns have been expressed about immunity against COVID-19 not lasting. We used this study to investigate that question and found immunity is stable for at least five months," who led the study, published today in the journal Immunity, alongside Professor Janko Nikolich-Zugich from UArizona.


When a virus first infects cells, the immune system deploys short-lived plasma cells that produce antibodies to immediately fight the virus, the researchers explained.

Those antibodies appear in blood tests within 14 days of infection, they said.

The second stage of the immune response is the creation of long-lived plasma cells, which produce high-quality antibodies that provide lasting immunity, according to the researchers.

Deepta Bhattacharya and Janko Nikolich-Zugich tracked antibody levels over several months in people who tested positive for SARS-CoV-2 antibodies.

They found SARS-CoV-2 antibodies are present in blood tests at viable levels for at least five to seven months, although they believe immunity lasts much longer.

"Whether antibodies provide lasting protection against SARS-CoV-2 has been one of the most difficult questions to answer," said UArizona Health Sciences Senior Vice President Michael D Dake.

"This research not only has given us the ability to accurately test for antibodies against COVID-19, but also has armed us with the knowledge that lasting immunity is a reality," Mr. Dake said.

Earlier studies extrapolated antibody production from initial infections and suggested antibody levels drop quickly after infection, providing only short-term immunity.

Mr. Bhattacharya believes those conclusions focused on short-lived plasma cells and failed to take into account long-lived plasma cells and the high-affinity antibodies they produce.

"The latest time-points we tracked in infected individuals were past seven months, so that is the longest period of time we can confirm immunity lasts," Mr Bhattacharya said.

He said people who were infected with the first SARS coronavirus, which is the most similar virus to SARS-CoV-2, are still seeing immunity 17 years after infection.

"If SARS-CoV-2 is anything like the first one, we expect antibodies to last at least two years, and it would be unlikely for anything much shorter," the scientist added.

 

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